Mouse Bladder Carcinogenicity of Certain Tryptophan Metabolites and Other Aromatic Nitrogen Compounds Suspended in Cholesterol.
نویسندگان
چکیده
The carcinogenicity of seven metabolites of the essential amino acid tryptophan and nine other nitrogen-containing aromatic compounds was studied by the individ ual suspension of these chemicals in cholesterol pellets and the surgical implantation of the pellets into the bladders of mice. Pellets consisting of the 8-methyl ether of xanthurenic acid, xanthurenic acid, 8-hydroxyquinaldic acid, 3-hydroxy-L-kynurenine, and 3-hydroxyanthranilic acid—all metabolites of tryptophan—and N-hydroxy^acetylaminofluorene, Ar-acetyl-2-naphthylhydroxylamine, and 2-naphthylhydroxyl-
منابع مشابه
In Vivo Elution of Tryptophan Metabolites and Other Aromatic Nitrogen Compounds from Cholesterol Pellets Implanted into Mouse Bladders.
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متن کاملOrigin and Historical Perspective on Reactive Metabolites Abbreviations AFB1 Aflatoxin B1 BQ Benzoquinone BSA Bovine serum albumin CYP Cytochrome P450 GSH Glutathione GSSG Glutathione disulfide NAPQI N-Acetyl-p-benzoquinoneimine TCPO 1,2-Epoxy-3,3,3-trichloropropane TFA Trifluoroacetic acid TFAC Trifluoroacetyl chloride
The concept that chemicals, including drugs, could exert harmful effects on living organisms by their conversion into reactive metabolites probably dates back to the 1950s. The most compelling evidence began to be drawn in the 1960s from the area of carcinogenicity and studies looking at processing by metabolism of compounds to unstable, reactive metabolites. These studies drew from the human o...
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ورودعنوان ژورنال:
- Cancer research
دوره 24 شماره
صفحات -
تاریخ انتشار 1964